|
KMID : 0379520190350020191
|
|
한국독성학회지
2019 Volume.35 No. 2 p.191 ~ p.200
|
|
|
A 90-Day Repeated Oral Dose Toxicity Study of Alismatis Rhizoma Aqueous Extract in Rats
|
|
Lee Mu-Jin
Jung Hee-Jae
Lee Ki-Ho
Jang Ji-Hun
Sim Mi-Ok
Seong Tea-Gyeong
Ahn Byung-Kwan
Shon Jin-Han
Ham Seong-Ho
Cho Hyun-Woo
Kim Yong-Min
Park Sung-Jin
Yoon Ji-Young
Ko Je-Won
Kim Jong-Choon
|
|
|
Abstract
|
|
|
|
Alismatis rhizoma (AR), the dried rhizome of Alisma orientale (Sam.) Juzep, is a well-known, traditional medicine that is used for the various biological activities including as a diuretic, to lower cholesterol and as an anti-inflammatory agent. The present study was carried out to investigate the potential toxicity of the Alismatis rhizoma aqueous extract (ARAE) following 90-day repeated oral administration to Sprague-Dawley rats. ARAE was administered orally to male and female rats for 90 days at 0 (control), 500, 1,000 and 2,000 mg/kg/day (n = 10 for male and female rats for each dose). Additional recovery groups from the control group and high dose group were observed for a 28-day recovery period. Chromatograms of ARAE detected main compounds with four peaks. Treatment-related effects including an increase in the red blood cells, hemoglobin, hematocrit, albumin, total protein, and urine volume were observed in males of the 2,000 mg/kg/day group (p < 0.05). However, the diuretic effect of ARAE was considered, a major cause of hematological and serum biochemical changes. The oral no-observed-adverse-effect level (NOAEL) of the ARAE was > 2,000 mg/kg/day in both genders, and no target organs were identified.
|
|
|
KEYWORD
|
|
|
Alismatis rhizome aqueous extract, Traditional medicine, Diuretic effect, Sub-chronic toxicity, NOAEL
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
 
|
|